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Peptides changelog

1.27.3 (2025-11-12)​

  • Fix mutation cliffs viewer not updating on filter change
  • Fix mutation cliffs viewer not restoring selection on frame re-attach
  • Sequence variability map: filter out absent monomers from grid when filter is applied

1.27.0 (2025-11-10)​

  • Rework mutation cliffs and tooltips, shown information about sequence pairs and their statistics.

1.26.2 (2025-11-08)​

  • Add Current row tracking option to mutation cliffs viewer

1.26.1 (2025-11-07)​

  • Sequence mutation cliffs viewer: Initial release

1.26.0 (2025-11-05)​

  • Full filter reactivity for all panels, tooltips, aggregations and viewers
  • Corrected aggregate calculations, statistics and mean difference comparisons
  • Fix MCL viewer premature shutdown on loading

1.25.1 (2025-11-05)​

  • Fix distribution tooltips not showing on weblogo hover
  • Enable filter reactivity by default SAR viewers

1.25.0 (2025-11-04)​

  • Update dependencies
  • Enable filter reactivity for All Peptides Viewers (Invariant Map, Monomer-Position, Most Potent Residues, Logo Summary Table, WebLogo in header)
  • Got rid of target column for Peptides analysis
  • Add sum columns for Monomer-Position
  • Fix navigation bugs

1.23.14 (2025-06-17)​

  • Default selection grid for Peptides analysis

1.23.11 (2025-05-26)​

  • Fix model loading with empty cluster selection

1.23.10 (2025-05-15)​

  • Improved description for position statistics viewer

1.23.9 (2025-05-14)​

  • Reveerse events for Position statistics viewer

1.23.8 (2025-05-12)​

  • Performance improvements to Peptide viewers
  • LST white space reduction
  • Bug fixes
  • Position statistics viewer

1.23.6 (2025-04-30)​

  • Fix Peptides analysis not starting on data with existing position columns

1.23.5 (2025-04-22)​

  • Fix invisible Scroller in mutations cliffs

1.23.4 (2025-04-21)​

  • Fixes for selection table for DG null values
  • Correction of unselection for standalone viewers
  • Cosmetic corrections to null values in predictions

1.23.3 (2025-04-17)​

Selection widget: value retrieving fix

1.23.2 (2025-04-14)​

  • Manual setting of notation providers to tables

1.22.0 (2025-03-22)​

  • Fixed unhighlighting of header weblogo
  • Harmonization of selection and counts in monomer-position and MPR viewers
  • Added more comprehensive tooltips

1.21.7 (2025-03-17)​

  • Fixes and improvements of Selection panel

1.21.6 (2025-03-13)​

  • Fix demo and compatibility to older platform versions

1.21.5 (2025-03-12)​

  • Fix weblogo renderer with corrected colors and background corrections
  • Improved mutation cliffs preview window with horizontal splitter
  • Correct circle rendering in Monomer-Position viewer
  • Mutations groups column in mutation cliffs pairs panel

1.21.4 (2025-03-03)​

Fix SAR errors on nulling targets

1.21.3 (2025-02-28)​

MCL: Sparse matrix pruning to avoid browser crash

1.21.2 (2025-02-03)​

Correct Sizing of mutation cliff grids

1.21.1 (2025-01-10)​

LST: Fix flickering and incorrect rendering in some cases

1.21.0 (2025-01-06)​

Enable Project saving for SAR analysis

1.19.1 (2024-12-10)​

Fix JS-API related changes

1.19.0 (2024-11-01)​

Migrate to new seqHelper API

1.18.7 (2024-10-17)​

Fixes For GROK-16606, GROK-16609

1.18.6 (2024-10-08)​

MCL: Better layout for similar size clusters

1.18.5 (2024-10-07)​

Fix weblogo support

1.18.4 (2024-10-03)​

Use monomer tooltip from library

1.18.3 (2024-10-02)​

Add Monomer meta columns to the Monomer-Position viewer

1.18.2 (2024-09-22)​

Color monomer background in invariant map

1.18.1 (2024-09-18)​

Add monomer custom coloring

1.17.29 (2024-08-14)​

Update MCL implementation

1.17.28 (2024-08-08)​

  • Downgrade API version

1.17.27 (2024-08-08)​

  • Selection viewer restoring original grid sorting
  • MCL viewer limiting max intercluster lines
  • fix bugs with selections context panel

1.17.26 (2024-08-07)​

Rename monomer position viewer to sequence variability map

1.17.25 (2024-08-06)​

Update MCLalgorytm and Add params to starting menu

1.17.24 (2024-07-29)​

Fix invariant map values rendering

1.17.23 (2024-07-29)​

Added options to invariant map:

  • split selection for targets
  • coloring options via aggregation
  • value aggregation
  • tooltips
  • improved stability

1.17.22 (2024-07-22)​

Fix Active peptide selection viewer failing on frame attached.

1.17.21 (2024-07-12)​

Add support for string aggregation with pie chart viewer in LST viewer.

1.17.20 (2024-07-09)​

MCL: Reverse order of clusters

1.17.19 (2024-07-01)​

Fix dialog styles

1.17.18 (2024-05-27)​

Add inflation factor to MCL.

1.17.17 (2024-05-06)​

Add both annotations to the active peptide selection viewer.

1.17.16 (2024-04-29)​

Add thresholds to active peptide selection viewer.

1.17.15 (2024-04-17)​

Cluster max activity viewer working on level of cluster, not cluster size.

1.17.14 (2024-04-15)​

Fix display of the max activity vs cluster size viewer columns.

1.17.13 (2024-04-02)​

Features​

  • Add max activity vs cluster size viewer.

1.17.12 (2024-03-30)​

Features​

  • #2707: Add original and canonical to ISeqSplitted

1.17.11 (2024-03-12)​

  • Fix context panel issues with mutation cliff pairs.
  • Fix filter crashing app and never recovering.
  • Precompute mutation cliffs statistics for correct rendering.
  • Use mutation cliffs statistics for rendering (instead of invariant map data)
  • Use Count and mean difference for size and color of mutation cliffs table.
  • Correct tooltip for mutation cliffs table to use mutation cliffs stats.

1.17.10 (2024-02-29)​

Fix context panel crashing and never recovering

1.17.9 (2024-02-29)​

Fix Logo summary table not calculating for single clusters and not updating on filter.

1.17.8 (2024-02-22)​

Allow using qnum activity columns when running SAR analysis from top menu.

1.17.7 (2024-02-22)​

Allow using qnum activity columns.

1.17.6 (2024-02-20)​

Fix NW Distance function.

1.17.5 (2024-02-15)​

Added MCL clustering to peptide analysis.

1.17.3 (2024-02-01)​

  • Sequence space random seeding for reproducibility.
  • Use of generated clusters for summery web logo table.

1.17.2 (2023-12-26)​

  • Improved dimensionality reduction (sequence space).

1.17.0 (2023-11-29)​

Features​

  • Renamed activity column to Activity (previously: Scaled activity).
  • Improved input tooltip in the Mutation Cliffs pairs panel.
  • Autosize grids in the Mutation Cliffs pairs panel.
  • Hid sequence space embedding columns and axes selectors.
  • Saving context panels state.
  • Selected cells now have an orange thick border.
  • Distribution panel now shows distribution for (1) all activity values, (2) selected rows, (3) peptides selection from viewers if mismatched with the total selection.
  • Sequence space viewer now uses the Needleman-Wunsch algorithm to compute distances.
  • Linearization of helm format macromolecules before sequence space computation.
  • Improved rendering speed of invariant map (no lags).
  • Improved rendering speed upon selection/filtering.

Bug Fixes​

  • Fixed accordion wouldn't update after selection in table view.
  • Filtering dataframe causing most potent residues viewer and context panel to crash.
  • Filtering dataframe causing major lags.
  • Most potent residues viewer crashing on some data.
  • Weblogo viewer crashing or causing major lag on selection/filtering.

1.16.0 (2023-11-05)​

Features​

  • Added Select All and Deselect All functionality to all viewers.
  • Added Mean activity column for the Most Potent Residues viewer.
  • Added Mean activity to tooltips.
  • Added WebLogo to the Selection table.

Bug Fixes​

  • Fixed Logo Summary Table tooltip wouldn't show if the analysis table doesn't contain column name 'Cluster'.
  • Fixed tooltips would show irrelevant info.

1.15.3 (2023-10-26)​

Bug Fixes​

  • Fixed docking sequence space would completely remove the viewer.

1.15.2 (2023-10-26)​

Features​

  • Improved Sequence space default parameters (changed threshold similarity from 0.8 to 0.3)

1.15.1 (2023-10-19)​

Features​

  • Color-coding Sequence space by scaled activity.
  • Optimized Mutation Cliffs calculations to use workers.
  • Hid WebLogo positions in Logo Summary Table.

Bug Fixes​

  • Fixed Invariant Map color coding wouldn't change when changing the color column.

1.15.0 (2023-10-12)​

Features​

  • Added Sequence Space viewer.
  • Selection panel columns now inherit width from the main table.
  • Invariant Map cell values are now rendered with contrast color relative to the background.

Bug Fixes​

  • Fixed WebLogo in header margin width.
  • Widgets in Context panel will now fill all the available width.
  • Fixed LST rows are not resizable.
  • Fixed selection inconsistency.
  • Fixed Most Potent Residues keyboard navigation.
  • Fixed analysis not starting when there are columns of the same name.

1.14.1 (2023-09-28)​

Bug Fixes​

  • Fixed a bug when filtering single cluster would break Logo Summary Table.

1.14.0 (2023-09-28)​

Features​

  • Added keyboard navigation to Logo Summary Table, Monomer-Position, Most Potent Residues viewers and Mutation Cliff pairs panel.
  • Added icon to expand grids in property panel to fullscreen.

Bug Fixes​

  • Fixed Distribution panel labels.

1.13.3 (2023-09-20)​

Features​

  • WebLogo now reacts to filtering.

Bug Fixes​

  • Fixed distribution panel throwing error when selection matches filter.

1.13.2 (2023-09-14)​

Bug Fixes​

  • Downgraded datagrok-api dependency to version 1.16.4.

1.13.1 (2023-09-13)​

Bug Fixes​

  • Most Potent Residues: Fixed issue when the viewer failed to construct in some cases.

1.13.0 (2023-09-13)​

Features​

  • Monomer-Position and Most Potent Residues: Circle size is now based on the absolute value of mean difference.
  • Scaling default colors (blue for low values and red for high) in Monomer-Position viewer.
  • Highlight rows on mouse over Monomer-Position, Most Potent Residues, Logo Summary Table and WebLogo in the header.
  • Changed viewer interactivity to match the platform defaults. Learn more about viewer hotkeys here.
  • Accordion with actions, mutation cliffs pairs, distribution and selection panels now shows on any selection.
  • Removed steps from tutorial.
  • Ignore rows with missing values when starting the analysis.

Bug Fixes​

  • Logo Summary Table: Fixed interaction.

1.12.0 (2023-08-30)​

Features​

  • Added sequence identity and similairty functionality.
  • Peptides moved to Bio > Analyze > SAR.
  • Added tooltips for all inputs and buttons.
  • Added Selection panel which shows the current selection as a separate table.
  • UI/UX improvements.

Bug Fixes​

  • Fixed table view tooltips.
  • Fixed selection with WebLogo in the column header.
  • Fixed table view couldn't be filtered by monomer position columns.

1.11.0 (2023-08-03)​

This release introduces sequence identity functionality and some stability and usability improvements.

Features​

  • Added sequence identity functionality.
  • UI/UX improvements.
  • Added activity column choice in settings.

1.10.4 (2023-08-01)​

Features​

  • UI/UX improvements.

Bug Fixes​

  • Fixed Monomer-Position viewer not responding to selection correctly.

1.10.3 (2023-07-31)​

Bug Fixes​

  • Fixed wrong values in the invariant map.
  • Fixed Mutation Cliffs pair selection would still result in wrong sequences sometimes.

1.10.2 (2023-07-24)​

Bug Fixes​

  • Made invisible Mutation Cliffs pairs columns, containing sequence indexes in the original table view.

1.10.1 (2023-07-24)​

Features​

  • Invariant Map is now selecting sequences instead of filtering.
  • Minor UI/UX adjustments.

Bug Fixes​

  • Fixed mutation pair selection resulted in wrong unique sequences in the Mutation Cliffs bug.
  • Fixed position column labels not showing if the page was scaled.

1.10.0 (2023-07-19)​

This release focuses on improving analysis stability and usability.

Features​

  • Improved activity distribution plots to show selected vs. all.
  • Added position number in main table view column headers.
  • The Monomer-Position viewer in the Mutation Cliffs mode now shows the number of unique sequences that have monomer mutation at the selected position.
  • The Monomer-Position viewer in the Mutation Cliffs mode now selects unique sequences that have monomer mutation at the selected position.
  • The Mutation Cliffs panel now shows unique sequences and corresponding values from columns visible in the table view.

Bug Fixes​

  • Fixed bug when filter couldn't be applied to the original table after analysis started.